4DOSY – Advanced and Efficient DOSY Data Processing
CASC4DE offers 4DOSY, an innovative platform for processing 2D DOSY NMR experiments using a robust combination of PALMA algorithm and Maximum Entropy / L1 hybrid regularization.
🧪 NMR is a powerful tool to determine diffusion coefficients in solution, especially useful in complex mixtures, molecular interactions, or polymer systems. The inverse Laplace transform (iLT) required for DOSY interpretation is efficiently handled by the 4DOSY engine.
This solution is based on the following publication:
PALMA, an improved algorithm for DOSY signal processing
A. Cherni, E. Chouzenoux and M.-A. Delsuc, Analyst, 2017, 142, 772–779
🚀 Key Features
- Robust processing of monodisperse and polydisperse systems
- Noise-resilient results thanks to hybrid MaxEnt / L1 regularization
- Fast convergence through proximal splitting algorithms
- Fully online, automated and secure data submission & result delivery
- Support for Bruker data (Jeol support in development)
- Compatible with multiple DOSY pulse sequences (pgse, ste, bpp_ste, BPP_LED, etc.)
📷 Example Output
Figure extracted from the paper cited above, representative of the results that can be obtained using 4DOSY:
Comparison of DOSY experiments on a brown algae extract.
a) Original sample
b) Sample with added chloroquine
c) 1D spectrum
(Aromatic region scaled 4× lower than aliphatic for clarity)
💶 Pricing
💻 Annual Access to the 4DOSY Web Platform
Single-user license – 12 months
Includes:
- 24/7 access (excluding maintenance)
- Up to 1,400 analyses/year
- Email support
- Results returned within 1–2 hours (TopSpin format, ZIP delivery)
- PALMA-based MaxEnt processing with customizable thresholds
👉 Price: 3 500 € excl. VAT
💬 Additional analyses beyond 1,400/year can be quoted on request.
🛠️ Custom Options
On-site installation or local deployment:
We can develop an on-premise version of 4DOSY tailored to your infrastructure.
🧑💻 Available on request, via personalized quotation.
Custom development / advanced options:
Need specific features, custom pulse sequences, or integration?
We can tailor the platform to your needs.
📝 Quoted on demand.
📩 Try the Demo
Interested in testing the platform?
Contact us to request an access to the server for a demo and see 4DOSY in action.