Our research publications

CASC4DE is a company specialized in the development of analytical methods along with software and data engineering. Here are reported our latest publications illustrating some of our research focus areas.


Ultra-Accurate Correlation between Precursor and Fragment Ions in Two-Dimensional Mass Spectrometry: Acetylated vs Trimethylated Histone Peptides M. Palasser, S. V. Heel, M-A. Delsuc, K. Breuker, and M. A. van Agthoven. 2023 J. Am. Soc. Mass Spectrom.

Genetic evolution of a multi-generational population in the context of interstellar space travel Part I: Genetic evolution under the neutral selection hypothesis F. Marin, C. Beluffi, F. Fischer 2021 Journal of the British Interplanetary Society, 74, 162-184

Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry M.-A.Delsuc, K. Breuker, M.A. van Agthoven 2021 Molecules, 2021, 26, 3388

Application of Optimal Control Theory to Fourier Transform Ion Cyclotron Resonance V. Martikyan, C. Beluffi, S.J. Glaser, M.-A. Delsuc, D. Sugny 2021 Molecules, 26, 10: 2860

Narrowband Modulation Two-Dimensional Mass Spectrometry and Label-Free Relative Quantification of Histone Peptides M. Halper, M.-A. Delsuc, K. Breuker, and M.A. van Agthoven 2020 Anal. Chem., 92, 20, 13945–13952

Phase relationships in two-dimensional mass spectrometry M. A. van Agthoven, D. P. A. Kilgour, A. M. Lynch, M. P. Barrow, T. E. Morgan, C. A. Wootton, L. Chiron, M.-A. Delsuc, P. B. O’Connor 2019 J. Am. Soc. Mass Spectrom., 30(12) :2594-2607

Deconvolution of isotopic pattern in 2D-FTICR Mass Spectrometry of peptides and proteins L. Duciel, A. Cherni and M.-A. Delsuc. 2019 Chemical Physics, arXiv:1906.06218

Automatised Pharmacophoric Deconvolution of Plant Extracts, application to Cinchona bark crude extract L. Margueritte, L. Duciel, M. Bourjot, C. Vonthron-Sénécheau and M.-A. Delsuc 2019 Faraday Discussions, 218, 441-458

Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry M. A. van Agthoven, Y. P. Y. Lam, P. B. O’Connor, C. Rolando & M.-A. Delsuc. 2019 European Biophysics Journal, 48 :213–229

Automatic differential analysis of NMR experiments in complex samples L. Margueritte, P. Markov, L. Chiron, J.-P. Starck, C. Vonthron Sénécheau, M. Bourjot, and M.-A. Delsuc. 2018 Magn. Reson. Chem., 80(5) :1387

Computing the minimal crew for a multi-generational space journey towards Proxima Centauri b F. Marin, C. Beluffi 2018 Journal of the British Interplanetary Society, 71, 45-52

Application of Tandem Two-Dimensional Mass Spectrometry for Top-Down Deep Sequencing of Calmodulin F. Floris, L. Chiron, A. Lynch, M. P. Barrow, M.-A. Delsuc, and P. B. O’Connor. 2018 J. Am. Soc. Mass Spectrom., 29 :1700–1705

Top-Down Deep Sequencing of Ubiquitin using two-dimensional mass spectrometry F. Floris, L. Chiron, A. Lynch, M. P. Barrow, M.-A. Delsuc, and P. B. O’Connor. 2018 Anal. Chem., 90(12) :7302–7309

Numerical constraints on the size of generation ships from total energy expenditure on board, annual food production and space farming techniques F. Marin, C. Beluffi, R. Taylor, L. Grau 2018 Journal of the British Interplanetary Society, 71, 382

Can Two-Dimensional IR-ECD Mass Spectrometry Improve Peptide de Novo Sequencing? M.A. van Agthoven, A.M. Lynch, T.E. Morgan, C.A. Wootton, Y.P.Y. Lam, L. Chiron, M.P. Barrow, M.-A. Delsuc, and P.B. O’Connor 2018 Anal. Chem. 90, 5, 3496–3504

Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin F. Floris, M. A. van Agthoven, L. Chiron, C. A. Wootton, P. Y. Y. Lam, M. P. Barrow, M.-A. Delsuc, and P. B. O’Connor. 2018 J. Am. Soc. Mass Spectrom., 29(1) :207–210

Polymer analysis in the second dimension: preliminary studies for the characterisation of polymers with 2D MS F. Floris, C. Vallotto, L. Chiron, A. Lynch, M. P. Barrow, M.-A. Delsuc, and P. B. O’Connor. 2017 Anal. Chem., 89(18): 9892-9899

Nonuniform Sampling Acquisition of Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Increased Mass Resolution of Tandem Mass Spectrometry Precursor Ions F. Bray, J. Bouclon, L. Chiron, M. Witt, M.- A. Delsuc, and C. Rolando. 2017 Anal. Chem., 899170: 8589-8593

Uncoiling Collagen: A Multidimensional Mass Spectrometry Study H. J. Simon, M. A. van Agthoven, P. Y. Lam, F. Floris, L. Chiron, M.-A. Delsuc, C. Rolando, M. P. Barrow and P. B. O’Connor. 2016 The Analyst, 141, 157–165

Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with Cytochrome c M. A. van Agthoven, C. A. Wootton, L. Chiron, M. A. Coutouly, A. Soulby, J. Wei et al 2016 Anal. Chem., 88(8): 4409–4417

2D FT-ICR MS of Calmodulin: A Top-Down and Bottom-Up Approach F. Floris, M. van Agthoven, L. Chiron, et al. 2016 J. Am. Soc. Mass Spectrom., 27(9): 1531–1538

SPIKE a Processing Software dedicated to Fourier Spectroscopies L. Chiron, M.-A. Coutouly, J.-P. Starck, C. Rolando, M.-A. Delsuc. 2016 arXiv 1608.06777

Efficient denoising algorithms for large experimental datasets and their applications in Fourier transform ion cyclotron resonance mass spectrometry L. Chiron, M. A. van Agthoven, B. Kieffer, C. Rolando, and M-A. Delsuc. 2014 PNAS, 111(4): 1385-1390