PFAS and Neurotoxicity: An Emerging Concern for Brain Health

By CASC4DE January 14, 2025

PFAS and Neurotoxicity: An Emerging Concern for Brain Health

 

PFAS (per- and polyfluoroalkyl substances) have the alarming ability to bypass the blood-brain barrier and accumulate in brain cells. This highlights their neurotoxic potential and raises concerns about their long-term effects.

🔑 Key Findings

A recent study by Diana Aga and Ekin Atilla-Gokcumen at the University at Buffalo explored the cellular and molecular disruptions caused by six PFAS compounds using an in vitro model for neurodegenerative diseases.

  • 721 genes affected by combined PFAS exposure.
  • 11 key genes crucial for neuronal health were consistently disrupted.
  • PFAS modify gene expression based on their chemical structure, emphasizing the need for individual analysis of their impacts on brain biology.

🧬 Molecular Alterations Observed

PFAS exposure impacts:

  • Neuronal growth,
  • Synaptic signaling,
  • Overall cellular health.

These effects are mediated through complex transcriptomic and lipidomic disruptions, emphasizing their profound biological implications.

⚠️ Focus on PFOA: A Key Culprit

Among the compounds studied, perfluorooctanoic acid (PFOA) had the most severe effects, despite minimal absorption:

  • 584 genes affected, far surpassing the impact of other PFAS.
  • Significant reduction in gene expression related to synaptic growth and neuronal function, essential for brain development.

📜 Regulatory Implications

Understanding why certain PFAS are more hazardous could:

  • Guide their prioritization for elimination,
  • Help identify safer substitutes.

This groundbreaking study, published in ACS Chemical Neuroscience on December 18, underscores the urgent need to regulate PFAS effectively. Supported by the U.S. EPA, the research contributes critical insights for policymaking.


📚 Learn More
Full article: ACS Chemical Neuroscience